IMPACT OF MAGNESIUM SUPPLEMENTATION ON BONE MASS ACCRUAL IN ADOLESCENTS WITH SUBOPTIMAL MAGNESIUM INTAKE: A PILOT STUDY

Authors

  • Dr. C. Manjunath Associate Professor, Department of Orthopaedics, Sri Lakshmi Narayana Institute of Medical Sciences & Hospital, Puducherry - 605502 Author

DOI:

https://doi.org/10.48047/ffdf8v57

Keywords:

Magnesium, Bone mass, Adolescents, Bone mineral content, Supplementation

Abstract

Pilot in the study was an attempt to test the influence of magnesium (Mg) supplement on the accrual of bone mass in poor dieting adolescents on magnesium. The researchers selected premenarchal girls of ages 8-14 years old and assigned them to magnesium oxide (300mg/day) or placebo in a span of one year. Dual energy x-ray absorptiometry (DXA) was used to measure the bone mineral density (BMD) and bone mineral content (BMC) at baseline, after 6 months, and after 12 months. The increase in total hip BMC was also significantly greater in the Mg-treated group than a placebo group especially in the neck of the femur, total hip and Ward area. Whereas, the effect on the spinal BMC and BMD was comparatively small, the effect was positive in support of Mg group. Mg supplement was also safe and well tolerated and linked with a reasonable compliance. This paper has confirmed the possibilities of Mg supplement on bone health in early teens, and more studies are required on bigger populations.

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References

Wasnich RD. Epidemiology of osteoporosis. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd ed. Philadelphia-New York: Lippincott-Raven Publishers; 1996. p. 249.

Melton LJ., III Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989;129:1000–1011.

Zanchetta JR, Plotkin H, Filgueira MLA. Bone mass in children: normative values for the 2–20-year-old population. Bone. 1995;16:393S–399S.

Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heaney RP. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. J Clin Invest. 1994;93:799–808.

Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P. Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. J Clin Endocrinol Metab. 1997;82:429–434.

Marcus R. Physical activity and regulation of bone mass. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd ed. Philadelphia-New York: Lippincott-Raven Publishers; p. 254.

Bonjour J-P, Carrie A-L, Ferrari S, Clavien H, Stosman D, Theintz G, Rizzoli R. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. J Clin Invest. 1997;99:1287–1294.

Johnston CC, Miller JZ, Slemenda CW, Reister TK, Hui S, Christian JC, Peacock M. Calcium supplementation and increase in bone mineral density in children. N Engl J Med. 1992;327:82–88.

Lloyd T, Andon MB, Rollings N, Martel JK, Landis JR, Demers LM, Eggli DF, Kieselhorst K, Kulin HE. Calcium supplementation and bone mineral density in adolescent girls. JAMA. 1993;270:841–844.

Lee WTK, Leung SSF, Wang SH, Xu YC, Zeng WP, Lau J, Oppenheimer SJ, Cheng JC. Double-blind, controlled calcium supplementation and bone mineral accretion in children accustomed to a low-calcium diet. Am J Clin Nutr. 1994;60:744–750.

Lee WTK, Leung SSF, Leung DMY, Tsang HSY, Lau J, Cheng JCY. A randomized double-blind controlled calcium supplementation trial, and bone and height acquisition in children. Br J Nutr. 1995;74:125–139.

Boskey AL, Rimnac CM, Bansal M, Federman M, Lian J, Boyan BD. Effect of short-term hypomagnesemia on the chemical and mechanical properties of rat bone. J Orthop Res. 1992;10:774–783.

Cohen L. Recent data on magnesium and osteoporosis. Magnesium Research. 1988;1:85–87.

Carpenter TO. Disturbances of vitamin D metabolism and action during clinical and experimental magnesium deficiency. Magnesium Research. 1988;1:131–139.

Anast CS, Gardner DW. Disorders of mineral metabolism. Vol III. San Diego: Academic Press; 1981. Magnesium metabolism; p. 423.

Wallach S. Magnesium exchangeability and bioavailability in magnesium deficiency. In: Altura BM, Durlach J, Seelig MS, editors. Magnesium in cellular processes and medicine. Basel: Karger; 1985. p. 27.

Anast CS, Mohs JM, Kaplan Sl, Burns TW. Evidence for parathyroid failure in magnesium deficiency. Science. 1972;177:606–608. doi: 10.1126/science.177.4049.606.

Rude RK, Oldham SB, Singer FR. Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency. Clin Endocrinol (Oxf) 1976;5:209–224.

Rude RK, Adams JS, Ryzen E, Endres DB, Niimi H, Horst RL, Haddad JG, Jr, Singer FR. Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency. J Clin Endocrinol Metab. 1985;61:933–940.

Hebert SC. Extracellular calcium-sensing receptor: implications for calcium and magnesium handling in the kidney. Kid Int. 1996;50:2129–2139.

Dietary references intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press, Office of News and Public Information; 1997.

Federation of American Societies for Experimental Biology, Life Sciences Research Office. Prepared for the Interagency Board for Nutrition Monitoring and Related Research. Vol. 1, Table A.T6-16 ed. Washington, DC: U.S. Government Printing Office; 1995. p. 21.

Dimai H-P, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau K-HW. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998;83:2742–2748.

Stendig-Lindberg G, Tepper R, Leichter I. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research. 1993;6:155–163.

Rude RK, Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporosis Int. 1996;6:453–461.

Carpenter TO, Mackowiak SJ, Troiano N, Gundberg CM. Osteocalcin and its message: relationship to bone histology in magnesium-deprived rats. Am J Physiol. 1992;263:E107–E114.

Rude RK, Gruber HE, Wei LY, Frausto A, Mills BG. Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int. 2003;72:32–41.

Carpenter TO, Mitnick MA, Ellison A, Smith C, Insogna KL. Nocturnal hyperparathyroidism: a frequent feature of X-linked hypophosphatemia. J Clin Endocrinol Metab. 1994;78:1378–1383.

Gundberg CM, Hauschka PV, Lian JB, Gallop PM. Osteocalcin: isolation, characterization and detection. Methods Enzymol. 1984;107:516–544.

Ryschon TW, Rosenstein DL, Rubinow DR, Niemela JE, Elin RJ, Balaban RS. Relationship between skeletal muscle intracellular ionized magnesium and measurements of blood magnesium. J Lab Clin Med. 1996;127:207, 213.

Cohen L, Laor A, Kitzes R. Magnesium malabsorption in postmenopausal osteoporosis. Magnesium. 1983;2:139–143.

Angus RM, Sambrook PN, Pocock NA, Eisman JA. Dietary intake and bone mineral density. Bone Miner. 1988;4:265–277.

Houtkooper LB, Ritenbaugh C, Aickin M, Lohman TG, Going SB, Weber JL, Greaves KA, Boyden TW, Pamenter RW, Hall MC. Nutrients, body composition and exercise are related to change in bone mineral density in premenopausal women. J Nutr. 1994;125:1229–1237.

New SA, Bolton-Smith C, Grubb DA, Reid DM. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 1997;65:1831–1839.

Wang MC, Moore EC, Crawford PB, Hudes M, Sabry ZI, Marcus R, Bachrach LK. Influence of pre-adolescent diet on quantitative ultrasound measurements of the calcaneus in young adult women. Osteoporos Int. 1999;9:532–535.

Carpenter TO, Barton CN, Park YK. Usual dietary magnesium intake in NHANES III is associated with femoral bone mass. J Bone Miner Res. 2000;15 Suppl 1:S292.

CSF II. Nationwide Food Consumption Survey. Continuing Survey of Food Intakes by Individuals. Report No. 85-4. US Department of Agriculture, Human Nutrition Information Service, Nutrition Monitoring Division; 1985.

Bollen AM, Eyre DR. Bone resorption rates in children monitored by the urinary assay of collagen type I cross-linked peptides. Bone. 1994;15:31–34.

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Published

2026-02-10

How to Cite

IMPACT OF MAGNESIUM SUPPLEMENTATION ON BONE MASS ACCRUAL IN ADOLESCENTS WITH SUBOPTIMAL MAGNESIUM INTAKE: A PILOT STUDY (Manjunath C , Trans.). (2026). Cuestiones De Fisioterapia, 52(2), 344-351. https://doi.org/10.48047/ffdf8v57