Immunohistochemistry in Gastric Carcinoma: Diagnostic Subtyping, Prognostic Stratification, and Predictive Biomarkers
DOI:
https://doi.org/10.48047/jmj6cw65Keywords:
Immunohistochemistry, Gastric Carcinoma, BiomarkersAbstract
Background: Background: Gastric carcinoma remains a major cause of cancer-related mortality worldwide, largely because many patients present at advanced stage and because the disease comprises biologically diverse tumor entities with different pathways of carcinogenesis and treatment responsiveness. While histomorphology remains the foundation for diagnosis and classification, it does not fully capturethe molecular heterogeneity of gastric cancer or reliably predict prognosis
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References
Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 2020;21(11):4012. doi:10.3390/ijms21114012
Lin Y, Zheng Y, Wang HL, Wu J. Global patterns and trends in gastric cancer incidence rates (1988–2012) and predictions to 2030. Gastroenterology. 2021;161(1):116-127. doi:10.1053/j.gastro.2021.03.018
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