EFFICACY OF ONDANSETRON AND DEXAMETHASONE COMBINATION FOR PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN MAJOR GYNAECOLOGICAL SURGERY: A RANDOMIZED CONTROLLED TRIAL
DOI:
https://doi.org/10.48047/rhk97g45Keywords:
Postoperative nausea and vomiting (PONV), Ondansetron, Dexamethasone, Gynaecological surgery, Prophylactic treatmentAbstract
We examined 100 ASA I and II female operated on through general anaesthesia due to major gynaecological procedure, in prospective and blind and placebo-controlled randomised study. The four treatments provided to each of the subjects involved prevention of postoperative nausea and vomiting (PONV); i.e. ondansetron 4 mg (n = 25), dexamethasone 8 mg (n = 25), a combination of ondansetron and dexamethasone (4 mg and 8 mg, respectively, n = 25) or placebo (saline, n = 25). The groups did not show significant variations in the characteristics at the baseline and in the variables related to a surgery and anaesthesia, morphine use, and pain levels or side effects. Nausea and vomiting rate of the ondansetron and dexamethasone treated group was lower than placebo (P = 0.01), ondansetron (P = 0.05) and dexamethasone (P = 0.057) group. Comparison of Ondansetron with dexamethasone did not give any significant difference though the medications were effective as compared to placebo (P = 0.05 and P = 0.01 respectively). Dexamethasone was established to prohibit the incidence of nausea to a greater extent than that of vomiting. Antiemetic rescue was required by fewer patients in the ondansetron and dexamethasone combination arm than in placebo (P = 0.01), and ondansetron (P = 0.05). Our conclusion is based on prophylactic consumption of combined ondansetron with dexamethasone in order to stop PONV. (Br. J. The youth believed in the case study that where it involves an elderly child, there are high chances of this child recording it wrong by the elderly child (Anaesth. 1996; 76: 835-840).
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