Parthenolide as an Experimental Antifibrotic Agent: Mechanistic Insights and Therapeutic Prospects in Renal Fibrosis
DOI:
https://doi.org/10.48047/bbn77w83Keywords:
Parthenolide, Antifibrotic Agent, Renal FibrosisAbstract
Background: Renal fibrosis represents the final common pathway of most chronic kidney diseases (CKD), leading to progressive nephron loss and decline in renal function. Current therapeutic options remain limited, largely supportive, and unable to halt or reverse established fibrotic remodeling. Parthenolide, a sesquiterpene lactone extracted from Tanacetum parthenium (feverfew), has garnered significant interest due to its potent anti-inflammatory and
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References
Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 2011;7(12):684–696.
Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in chronic kidney disease. N Engl J Med. 2020;383:1436–1446.
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