Semaglutide and Neuroprotection: Exploring Mechanisms Against Ischemia-Reperfusion Injury Beyond Glycemic Control

Authors

  • El-Sayed Mohamed Kamel, Amira Mohamed Abdelhamid, Haidy Mohamed Ali Mohamed , Yasmeen Mahmoud Elsayed Author

DOI:

https://doi.org/10.48047/5fa5a083

Keywords:

Semaglutide, Neuroprotection, Ischemia-Reperfusion Injury , Glycemic Control

Abstract

Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, with ischemia-reperfusion (I/R) injury 
representing a major therapeutic challenge. Restoration of blood flow, though essential, paradoxically exacerbates neuronal damage through oxidative stress, excitotoxicity, inflammation, and mitochondrial dysfunction. Despite progress in reperfusion therapies such asthrombolysis and mechanical thrombectomy, effective 

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References

Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003;4(5):399415.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Semaglutide and Neuroprotection: Exploring Mechanisms Against Ischemia-Reperfusion Injury Beyond Glycemic Control (El-Sayed Mohamed Kamel, Amira Mohamed Abdelhamid, Haidy Mohamed Ali Mohamed , Yasmeen Mahmoud Elsayed , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 6419-6426. https://doi.org/10.48047/5fa5a083