SGLT-2 Inhibition Beyond Glycemic Control: Exploring the Neuroprotective Properties of Dapagliflozin in Diabetes-Related Neurodegeneration
DOI:
https://doi.org/10.48047/mbw59m89Keywords:
SGLT-2, Neuroprotective, DapagliflozinAbstract
Background: Diabetes mellitus is increasingly recognized not only as a metabolic disorder but also as a condition that predisposes the central nervous system to accelerated aging and neurodegeneration. Chronic hyperglycemia, oxidative stress, neuroinflammation, and mitochondrial dysfunction collectively contribute
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References
Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591-604.
Butterfield DA, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 2019;20(3):148-160.
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