Doxorubicin-Induced Apoptosis in Murine Cancer Model: A Gene Expression Profiling Study
DOI:
https://doi.org/10.48047/0nencd54Keywords:
Cancer, doxorubicin chemotherapy, PCR; apoptosisAbstract
Background: Objectives: Doxorubicin (Dox) used in cancer treatment in female mice as an experimental animal.
Methods: Mice were treated intraperitoneally with 0.026 mg/ml of doxorubicin chemotherapy once every 7 days ucedfor 30 days. Simultaneously, mice received distilled water by oral gavage or were intraperitonially injected with a single dose of Ehrlich Ascites Carcinoma and kept as negative and positive controls, respectively. Real-time PCR technique were used to evaluate the apoptosis in the liver of treated mice.
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Chen, M., Yi, Y., Chen, B., Zhang, H., Dong, M., Yuan, L., ... and Ma, Z., 2024. Metformin inhibits OCTN1-and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice. Toxicol. 503, 153757.
Gilliam, L. A., Lark, D. S., Reese, L. R., Torres, M. J., Ryan, T. E., Lin, C. T., ... & Neufer, P. D., 2016. Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. American Journal of Physiology-Endocrinology and Metabolism, 311(2), E293-E301.
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