Evaluation of the Anticancer Potential of a Polyherbal Vaginal Gel Against DMBA-Induced Vaginal Carcinoma in Wistar Rats

Authors

  • Mr. Utkarsh R. Mandage, Ms. Pranali Pralhad Patil, Ms. Sushma Prabhakar Patil, Ms. Megha Prashant Parab, Ms. Prajkta Sanjay Mahajan, Ms. Komal Vilas Bhangale, Ms. Samiksha Sudhakar Lokhande Author

DOI:

https://doi.org/10.48047/2ct3yd27

Keywords:

Polyherbal vaginal gel, vaginal carcinoma, DMBA-induced cancer, antioxidant activity, anti-inflammatory markers, apoptotic pathway, topical drug delivery, Wistar rats.

Abstract

This study looked at how well a polyherbal vaginal gel fights vaginal cancer caused by 7,12dimethylbenz[a]anthracene (DMBA) in Wistar rats. The gel was made from extracts of Curcuma longa (turmeric), Aloe vera, Azadirachta indica (neem), and several other traditional herbs. After tumors formed, the gel was applied directly to the vagina. The results showed a big drop in tumor size and a later tumor appearance in animals treated with the gel. The group that got

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References

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48.

Aggarwal BB, Gupta SC, Sung B. Curcumin: A multi-functional anti-cancer agent. Br J Pharmacol. 2020;171(6):1119–1130.

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Published

2024-03-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Evaluation of the Anticancer Potential of a Polyherbal Vaginal Gel Against DMBA-Induced Vaginal Carcinoma in Wistar Rats (Mr. Utkarsh R. Mandage, Ms. Pranali Pralhad Patil, Ms. Sushma Prabhakar Patil, Ms. Megha Prashant Parab, Ms. Prajkta Sanjay Mahajan, Ms. Komal Vilas Bhangale, Ms. Samiksha Sudhakar Lokhande , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 5269-5285. https://doi.org/10.48047/2ct3yd27