Synthesis, Characterization, Anti-mycobacterial evaluation, In Vitro and Computational analysis of Pyrazole derivative
DOI:
https://doi.org/10.48047/f0n1z609Keywords:
Pyrazole, Hydrazides, antituberculosis, ADMET-SAR, drug design, pharmacokinetics.Abstract
Pyrazole derivatives have gained considerable interest in medicinal chemistry due to their diverse pharmacological properties, including antituberculosis activity. This study focuses on the synthesis, characterization, ADMET-SAR predictions, and biological evaluation of substituted pyrazole derivatives of 3-(4-methoxyphenyl)-3-oxopropanoate.) The synthesized compounds were characterized using spectral techniques, including NMR, IR, and mass spectroscopy. ADMET-SAR analysis predicted the pharmacokinetics and drug-likeness of these compounds, and their antituberculosis activity was evaluated against Mycobacterium tuberculosis strains. The results indicated promising biological activity and favourable drug-like properties, suggesting their potential as lead molecules for the development of antituberculosis drugs.
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References
Faisal M, Saeed A, Hussain S, Dar P, Larik FA. Recent developments in synthetic chemistry and biological activities of pyrazole derivatives. J Chem Sci. 2019 Aug 1;131(8).
Srivastava S, Kumar Rajput N, Rajendiran K, Lal Guru Jambheshwar K, Kumar N, Kanagaraj R, et al. Modeling molecular interactions of propounded pyrazole based drug candidates against bacterial DNA gyrase: Validation by syntheses and biological studies. Artic J Mol Struct [Internet]. 2019 [cited 2020 Sep 20]; Available from: https://doi.org/10.1016/j.molstruc.2019.05.125
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