A prospective study comparing clonidine and diazepam for maternity remaining education, anxiolysis, and postoperatal pain management in pediatric patients
DOI:
https://doi.org/10.48047/d1rsj720Keywords:
clonidine, pediatric premedication, sedation, analgesia, anaesthesiaAbstract
This prospective study aimed to compare the efficacy of clonidine (2 mg/kg and 4 mg/kg), as a premedication in children undergoing reconstructive, orthopaedic, otological, or ophthalmological surgery to that of diazepam (0.2 mg/kg). One hundred children asa grade i, aged 3-15 years were taken and randomly assorted into three groups, clonidine 2 mg/kg (2c), clonidine 4 mg/kg (4c), and diazepam 0.2 mg/kg (d). Each group received the respective premedication 90 minutes prior to induction of anaesthesia. The research variables were sedation, parental separation, mask acceptance and pain scores perioperative period. The groups that received clonidine expressed a significantly higher sedation, parental separation, and mask acceptance compared to diazepam group. The clonidine groups had also lower pain scores, and required less rescue analgesia. Also, clonidine provided no pertinent changes in the respiratory frequency or desaturation, not to mention that no severe respiratory depression was observed. However, clonidine 4 mg/kg resulted in minor incidence of hypotension and bradycardia that required conservative postoperative monitoring. The outcomes revealed that clonidine particularly at 2mg/kg dose is a nice and safer alternative of diazepam in premedication of children, which offers sedative, anxiolytic and analgesic effects with minimal side effects.
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References
Maze m, tranquilli w. Alpha-2 adrenoceptor agonists. Defining the role in clinical anaesthesia. Anesthesiology 1989; 74: 581-605.
Hayashi y, maze m. Alpha2 adrenoceptor agonists and anaesthesia. Br j anaesth 1993; 71: 108-18.
Tong c, eisenach jc. Alpha-2 adrenergic agonists. Anesthesiology cinics of north america 1994; 12: 49-63.
Khan jp, ferguson cn, jones rm. Alpha-2 and imidazolin receptor agonists. Anaesthesia 1999; 54: 146-65.
Wright pmc, carabine ua, mc clune s, orr da, moore j. Preanaesthetic medication with clonidine. Br j anaesth 1990; 65: 628-32.
Carabine ua, wright pmc. Moore j. Preanaesthetic medication with clonidine: a dose response study. Br j anaesth1991; 67: 79-83.
Paalzow l. Analgesia induced by clonidine in mice and rats. Journal of pharmacy and pharmacology. 1974; 26: 361-63.
Bonnet f, boico o, rostaing s et al. Extradural clonidine analgesia in postoperative patients. Br j anaesth 1989; 63(3):465-69.
Filos ks, goudas lc, patroni o, polyzou v. Intrathecal clonidine as a sole analgesic for pain relief after caesarean section. Anesthesiology 1992; 77: 267-74.
Jamali s, monan s, begon c et al. Clonidine in paediatric caudal anaesthesia. Anesth analg 1994; 78: 663-66.
Segal is, jarvis dj, duncan sr, white pe. Maze m. Clinical efficacy of oral and transdermal clonidine combination during the perioperative period. Anesthesiology 1991; 74: 220-25.
Mikawa k, nishina k, maekawa n, obara h. Oral clonidine premedication reduces postoperative pain in children. Anesth analg 1996; 82: 225-30.
Mikawa k, maekawa n, nishina k, takao y, yaku h. Obara h. Efficacy of oral clonidine premedication in children. Anesthesiology 1993; 79: 926-31.
Jarvis da, duncan sr, segal is, maze m. Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers. Anesthesiology 1992; 76: 899-905.
Ghignone m, quintin l, duke pc, kehler ch. Calvillo o. Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anaesthesia and endotracheal intubation. Anesthesiology 1986; 64: 36-42.
Ghignone m, calvillo o, quintin l. Anaesthesia and hypertension: the effect of clonidine on preoperative hemodynamics and isoflurane requirements. Anesthesiology 1987; 67: 3-10.
Pouttu j, scheinin b, rosenberg ph, viinamaki o. Scheinin m. Oral premedication with clonidine: effects on stress responses during general anaesthesia. Acta anaesthesiologica scandinavica 1987; 31: 730-34.
Flack jw, bloor bc, flack we, wong d, dazza s, stead sw, laks h. Reduced narcotic requirements by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery. Anesthesiology 1987; 67: 11-19.
Joris j, banache m, bonnet f. Clonidine and ketancerin both are effective treatment for postanesthetic shiveringanesthesiology 1993; 79: 532-39.
Orko r, pouttu j, ghignone m, rosenberg ph. Efficacy of clonidine on haemodynamic responses to endotracheal
Intubation and on gastric acidity. Acta anaesthesiologica scandinavica 1987; 31: 325-29.
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