FORMULATION AND EVALUATION OF DICLOFENAC SODIUM INJECTION
DOI:
https://doi.org/10.48047/t5701s80Abstract
This study focuses on the formulation and evaluation of a stable injectable dosage form of diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) with exceptional analgesic properties. The aim was to develop an effective parenteral solution suitable for intramuscular and intravenous administration, addressing the challenges posed by diclofenac sodium's low solubility and ensuring patient comfort during administration. The injectable formulation was prepared using solubilizing agents and excipients, and evaluated for key parameters including solubility, pH, osmolarity, physical appearance, weight per mL, and assay by HPLC. Results confirmed that the formulation met pharmacopoeial standards, with a clear, colourless appearance, a pH of 8.5, osmolarity of 568 mosm/kg, and 98.6% drug content. The findings indicate that the developed diclofenac sodium injection is stable, effective, and clinically suitable for treating a variety of acute and chronic pain conditions, ensuring reliable drug delivery and patient safety.
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