Pharmacological study on the Neuroprotective and Antioxidant Potential of Leucas aspera Methanolic extract
DOI:
https://doi.org/10.48047/58fmw977Keywords:
Antioxidants, Apoptosis, Chromatography, Leucas aspera, NeuroprotectiveAbstract
Investigation of the plant–based methanolic extract from the Leucas aspera has been proven to increase the antioxidant and neuroprotective potential like Parkinson’s and Alzheimer’s disease. Phytoconstituents extracted from the plant extract possess potential antioxidant and therapeutic qualities as a medicinal herb. Antioxidant tests such as the Ferric Reducing Antioxidant Power (FRAP) Free radical scavenging assay, the Phosphomolybdenum assay, and the Free radical scavenging assay (FRSA) were performed on methanolic extracts of Leucas aspera. Methanolic extract of the plant extract performed against aqueous and ethyl acetate and L-DOPA in terms of antioxidant activity of the plant extract evaluated from the results. The GC-MS analysis form the plant extract displayed the presence of key bioactive ingredients as 1-(1H-Imidazol-2-yl)-2,2-dimethyl-propan-1-one, cyclohexane carboxamide, ethyl tridecanoate, and docosanoic acid ethyl ester, oleonic acid, squalene, results from Thin layer chromatography (TLC) presence of flavonoids and phenolic compounds rich in neuroprotective activity. Scavenging the free radicals and modifying the oxidative stress involved in apoptosis and cell damage. Presence of catechins and epigallocatechins are specifically involved in safeguarding the neurons from excessive stress and oxidative damage. Herbal formulation extracted from Leucas aspera plant extract has strong antioxidant properties to chelate the metals and exhibits its medicinal value in reducing the neurodegenerative disorder, the study implies support of pharmacological utility of Leucas aspera plant extract regarding the development of neuroprotective medicines
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