BUOYANT MICRO BALLOONS: A NOVEL APPROACH FOR IMPROVED BIOAVAILABILITY OF METFORMIN
DOI:
https://doi.org/10.48047/v9p3a422Abstract
Abstract
In this research we focus on enhancing the bioavailability of Metformin, chemically a biguanide anti hyperglycaemic drug with poor solubility and permeability in the gut by utilizing gastric retention techniques. The work involves formulating six Metformin hollow micro balloons using two acid resistant polymers i.e Ethyl cellulose & Eudragit RS 100, in varying ratios to prolong gastric retention. Micro balloons were prepared by Emulsion solvent evaporation method with dichloromethane (DCM) & ethanol as a solvent system which is dropped into 10% HCl solution with high shear stirring .Prepared micro balloons were evaluated for various parameters out of six f4 was optimized , comprising a 1:2 ratio ( EC : ER RS 100) which exhibited significant characteristics including high buoyancy (80.19 ± 0.63%), excellent yield (88.84 ± 0.18%), substantial entrapment efficiency (85.63 ± 0.07%), and sustained drug release of 98.58 ± 0.45% over 12 hours. Scanning electron microscopy confirmed the desired hollow morphology and surface characteristics of the micro balloons. This optimized formulation holds promise for enhancing the therapeutic efficacy of Metformin through improved bioavailability and sustained release, potentially offering significant clinical benefits for patients with diabetes.
Keywords: Metformin, Ethylcellulose, Eudragit RS 100, DCM, Ethanol, entrapment efficiency. buoyancy, cumulative percentage drug release.
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