COMPARATIVE STUDIES BETWEEN REVERSE PHASE AND MIX MODE CHROMATOGRAPHY TOWARDS SIMULTANEOUS ESTIMATION OF SELECTED ANTIDIABETIC DRUGS
DOI:
https://doi.org/10.48047/0ke4f558Keywords:
chromatography, Mixed-mode chromatography, Lobeglitazone, Pioglitazone, Metformin, Simultaneous estimation, Drug recovery etc.Abstract
This study compares reverse-phase chromatography (RPC) and mixed-mode chromatography (MMC) for the simultaneous estimation of lobeglitazone, pioglitazone, and metformin in human plasma. Analytical challenges associated with the diverse physicochemical properties of these drugs-specifically the extreme hydrophilicity of metformin and moderate polarity of pioglitazone and lobeglitazone-were addressed using protein precipitation and solid-phase extraction techniques
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References
Kazakevich, Y., & LoBrutto, R. (2007). HPLC for Pharmaceutical Scientists. Wiley-Interscience.
Moldoveanu, S. C., & David, V. (2012). Essentials in Modern HPLC Separations. Elsevier.
Snyder, L. R., Kirkland, J. J., & Dolan, J. W. (2016). Introduction to Modern Liquid Chromatography (3rd ed.). Wiley.
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