Evaluation of biochemical and histopathological findings using Hesperetin against Huntington’s disease like symptoms induced by 3-Nitropropionic acid in rats
DOI:
https://doi.org/10.48047/rr58cy64Keywords:
Huntington’s disease, Hesperetin, 3-Nitropropionic acid, Oxidative stress, HistopathologyAbstract
The disease Huntington’s (HD) is an autosomal neurologic disorder characterized by inexorable loss of nerve
cells in the brain accompanied with cognitive, motor and psychiatric disorders. In the present study, 3
Nitropropionic acid (3-NPA), an inhibitor of mitochondrial citric acid cycle results in symptoms like HD.
Hesperetin(HSP) is a flavanone rich in citrus species which posses neuroprotective effects. The aim of the
present study was to evaluate the protective role of HSP against 3-NP induced symptoms. Pre-treatment of
animals with HSP/normal saline for 7 days and from 8th day, 3-NP (10mg/kg) was co-administered with HSP.
It is continued for 21 days of the treatment schedule. At the end day of the study, the results showed that HSP
improved all the cognitive, motor and psychiatric symptoms induced by 3-NP significantly. Further, oxidative
stress parameters, enzyme succinate dehydrogenase and neurochemical estimations were done in the brain
homogenate. The protective role of HSP further assessed by lesion area measurement with the 2,3,5
triphenyltetrazolium chloride staining of the brain slices and histopathological observations in hippocampus
(CA1 and CA3) and striatum. Hence, these findings show the protective effect of HSP against 3-NP induced
neurological disorder.
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