"Development and Validation of an RP-HPLC Method for the Simultaneous Estimation of Nortriptyline, Pregabalin, and Methylcobalamin in Pharmaceutical Dosage Forms”
DOI:
https://doi.org/10.48047/gw8zze36Keywords:
RP-HPLC, Nortriptyline, Pregabalin, Methylcobalamin, Simultaneous Quantification.Abstract
This study compares reverse-phase chromatography (RPC) and mixed-mode chromatography (MMC) for the simultaneous estimation of lobeglitazone, pioglitazone, and metformin in human plasma. Analytical challenges associated with the diverse physicochemical properties of these drugs-specifically the extreme hydrophilicity of metformin and moderate polarity of pioglitazone and lobeglitazone-were addressed using protein precipitation and solid-phase extraction techniques.
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References
Baron, R., Binder, A., & Wasner, G. (2017). Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment. The Lancet Neurology, 16(9), 835-847.
Berthod, A., Heinisch, S., & Staggemeier, B. (2019). Mixed-mode chromatography: A versatile tool for bioanalysis. Journal of Chromatography A, 1601, 223-240.
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