Association of Sestrin-2 for 8-hydroxy-20-deoxyguanosine and testosterone hormone level in patients with Polycystic Ovary Syndrome
DOI:
https://doi.org/10.48047/j0vsw746Keywords:
Sestrin2, 8-OHdG, Testosterone, Polycystic ovary syndrome, Oxidative stressAbstract
Approximately 6% to 20% of premenopausal women are affected with polycystic ovarian syndrome (PCOS), making it one of the most common endocrine disorders in reproductive-age women. Among the three types of stress responsive proteins that have persisted through evolution, Sestrin2 (SESN2) is present in the vast majority of vertebrates. Sestrin2, a recently discovered protein that is induced by a variety of stress conditions such as oxidative stress, inflammation, and DNA damage, is involved in the control of many vital cellular functions.
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References
R. Deswal, V. Narwal, A. Dang, and C. S. Pundir, "The prevalence of polycystic ovary syndrome: a brief systematic review," Journal of human reproductive sciences, vol. 13, no. 4, pp. 261-271, 2020.
R. Ziaei, Z. Shahshahan, H. Ghasemi‐Tehrani, Z. Heidari, M. S. Nehls, and R. Ghiasvand, "Inulin‐type fructans with different degrees of polymerization improve insulin resistance, metabolic parameters, and hormonal status in overweight and obese women with polycystic ovary syndrome: A randomized double‐blind, placebo‐controlled clinical trial," Food Science & Nutrition, vol. 12, no. 3, pp. 2016-2028, 2024.
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