A RESEARCH ON THE ENHANCEMENT OF COCAINE HYDROLASE FOR THERAPEUTIC INTERVENTION IN COCAINE-RELATED AGGRESSION
DOI:
https://doi.org/10.48047/s7syww48Keywords:
Pharmacological Metabolites, Metabolism, Drug Addiction, Cocaine.Abstract
A public health emergency exists due to the major problem of ineffective medicinal treatments for cocaine
addiction. The purpose of this study was to develop a synthetic enzyme, cocaine hydrolase (CocH), that
would mitigate the negative effects of cocaine on the brain and body. This enzyme would rapidly degrade
cocaine into harmless metabolites. To improve CocH's selectivity, stability, and catalytic activity while
reducing its off-target effects, the researcher explore the prospect of structural optimization in this work.
Enzyme design, in vivo and in vitro characterization of CocH variants, and preclinical evaluation of
therapeutic potential are the primary goals of research in this field. Animal models of drug-induced
behavioral responsiveness and cocaine metabolism were both enhanced by enhanced CocH. The study also
investigates potential immunogenicity, safety, and delivery techniques to ensure that CocH is suitable for
clinical usage.
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