A STUDY ON THE ADVANCEMENT OF COCAINE HYDROLASE FOR THERAPEUTIC INTERVENTION IN COCAINE-RELATED VIOLENCE
DOI:
https://doi.org/10.48047/j65p5b74Keywords:
Enzyme Security, Directed the Theory Of Evolution, Pharmacokinetics, Cocaine ToxicityAbstract
Lack of effective pharmaceutical therapies for cocaine addiction is a serious matter, posing a public
health emergency. The goal of this research was to create a synthetic enzyme called cocaine hydrolase
(CocH) that would lessen the cognitive and physiological harm that cocaine causes. Cocaine would be
broken down into inert byproducts very quickly by this enzyme. In this study, the researcher
investigate the possibility of structurally optimizing CocH to increase its selectivity, stability, and
catalytic activity while decreasing its off-target effects. Research in this area primarily aims to build
enzymes via protein design, characterize CocH variations in vivo and in vitro, and evaluate their
therapeutic potential in preclinical studies.
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