Next-Generation Antifungal Therapy: Miconazole Nitrate-Loaded Microspheres for Prolonged and Enhanced Drug Action
DOI:
https://doi.org/10.48047/chthkp19Keywords:
Miconazole Nitrate, Peppas Model, Microspheres, Entrapment Efficiency, Sustained Release, Excipients.Abstract
The current research focused on developing and characterizing sustained-release
microspheres of miconazole nitrate (MCN) with different polymers to optimize drug
entrapment efficiency and manage drug release. Microspheres were produced with an
optimized method and examined for particle size, surface topography, yield percentage,
drug content, entrapment efficiency, and in vitro drug release kinetic. Optical microscopy
and scanning electron microscopy (SEM) validated the spherical microspheres with a size
of 140–210 µm. The entrapment efficiency of the drug ranged from 72.06 ± 6.09 to 89.45
± 5.18 %, and the percentage yield was between 72.09 ± 5.22 and 92.60 ± 7.76 %. The in
vitro dissolution studies revealed sustained drug release over 12 h, with cumulative
release percentages of 81.80 ± 8.43 to 93.60 ± 8.77 %.
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