Toxicity And Risk Assessment of Sodium Fluoride at LD50 Concentration
DOI:
https://doi.org/10.48047/wrwrkg48Keywords:
Histopathology, LD50, Necrotic alterations, Necrosis, Post-mortem, Swiss albino mice, Sodium fluoride, Toxicological effects.Abstract
The study examined the toxicological effects of acute toxic Sodium fluoride (NaF) doses on Swiss albino mice. The lethal dose (LD50, which is the amount of a substance that is lethal to half of a group of test animals) method was used to determine the acute poisonous dose of NaF. The acute toxicity of NaF was tested on 4 healthy mice weighing 20-25 grams.
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References
Augenstein W, Spoerke D, Kulig K, Hall A, Hall P, Riggs B, Saadi M and Rumack B. 1991. Fluoride ingestion in children: a review of 87 cases. Pediatrics, 88: 907-912. 2. Dote T, Kono K, Usada K, Nishiura H, and Tagawa T. 2000. Acute renal damage dose response in rat to intravenous infusion of sodium fluoride. Fluoride, 33: 210-217.
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