Physiological Modulation of Neutrophil Activation and Recruitment by Heat Shock Protein 90 in Acute Pancreatitis

Authors

  • Mohammed Merza College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq. Author
  • Huda Jabbar Jawhar Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, Iraq Author
  • Zhian Sherzad Hayder College of Dentistry, Hawler Medical University, Kurdistan Region, Iraq. Author
  • Kewan Kamal Ahmad Department of Biology, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region- F.R. Iraq. Author
  • Roza Talaat Yaseen Department of Nursing, Faculty of Nursing, Tishk International University Author

DOI:

https://doi.org/10.48047/dwnp4j05

Keywords:

Amylase, Chemokines, Inflammation, Leukocytes, and Pancreas

Abstract

Background and Objective: Severe acute pancreatitis (AP) is characterized by leukocyte infiltration and tissue necrosis, yet the cellular signaling pathways driving pancreatic damage remain poorly understood. Heat shock protein 90 (HSP90) is a key regulator of specific cellular functions, promoting pro-inflammatory responses. This study investigates the role of HSP90 signaling in acute pancreatitis. 

Downloads

Download data is not yet available.

References

Liu X, Zheng Y, Meng Z, Wang H, Zhang Y, Xue D. Gene Regulation of Neutrophils Mediated Liver and Lung Injury through NETosis in Acute Pancreatitis. Inflammation. 2024.

Wetterholm E, Linders J, Merza M, Regner S, Thorlacius H. Platelet derived CXCL4 regulates neutrophil infiltration and tissue damage in severe acute

pancreatitis. Transl Res. 2016;176:105-18.

Dahiya DS, Jahagirdar V, Chandan S, Gangwani MK, Merza N, Ali H, et al. Acute pancreatitis in liver transplant hospitalizations: Identifying national trends, clinical outcomes and healthcare burden in the United States. World J Hepatol. 2023;15(6):797-812.

Downloads

Published

2025-02-20

Issue

Vol. 54 No. 4 (2025): Year 2025, Volume 54, Issue 4

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Merza, M. ., Jabbar Jawhar, H., Sherzad Hayder, Z. ., Kamal Ahmad, K., & Talaat Yaseen, R. . (2025). Physiological Modulation of Neutrophil Activation and Recruitment by Heat Shock Protein 90 in Acute Pancreatitis . Cuestiones De Fisioterapia, 54(4), 7245-7262. https://doi.org/10.48047/dwnp4j05