A Detector-Response Compensation Simulation Study With 3D MLEM in SPECT Compares Distance-Dependent and Distance-Nondependent Resolution Methods
DOI:
https://doi.org/10.48047/0gctbw53Keywords:
Detector-response compensation, SPECT, MLEM, Image quality assessment.Abstract
Background
Correcting spatial resolution in single photon emission computed tomography (SPECT) using iterative methods has proven effective in many studies. This correction involves using a projection matrix (projector) to simulate the acquisition of projections by a gamma camera, along with a back projection matrix (back-projector), which is generally the transpose of the projector without any
attenuation modeling. This study examined the contribution of distance-dependent detector-response compensation (DRC) and compared it to the accelerated version and the distance-nondependent method. Two projecttors (P1 and P2) and their corresponding back-projectors (B1 and B2) were implemented. P1 represented the distance-dependent response model, while P2 represented a nondependent average response model. Three reconstruction pairs were used: P1/B1 and P1/B2 for distance-dependent DRC, and P2/B2 for distance-nondependent DRC. The reconstruction method was the full 3D maximum-likelihood expectation maximization (MLEM), using simulated digital phantom projections that included attenuation, distance-dependent resolution, and Poisson noise without considering scatter.
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