NEUROPROTECTIVE EFFECTS OF MEDICINAL PLANTS IN ALZHEIMER’S DISEASE AND PARKINSON’S DISEASE
DOI:
https://doi.org/10.48047/pbgeat15Keywords:
Neurodegeneration, Alzheimer’s disease, Parkinson’s disease, medicinal plants, phytochemicals, oxidative stress, neuroinflammation, cholinesterase inhibitors, cognitive decline, neuroprotectionAbstract
Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by progressive neuronal loss, cognitive decline, and motor dysfunction. Current therapeutic strategies primarily focus on symptom management rather than disease modification. Medicinal plants have gained significant attention due to their neuroprotective properties, which include antioxidative, anti inflammatory, anti-amyloidogenic, and cholinesterase-inhibitory effects. Various phytochemicals, including flavonoids, alkaloids, and polyphenols, have shown potential in mitigating neurodegenerative processes by targeting oxidative stress, mitochondrial dysfunction, and neuroinflammation. This review explores the molecular mechanisms underlying the neuroprotective effects of medicinal plants, with a focus on key herbs such as Ginkgo biloba, Curcuma longa, Withania somnifera, Bacopa monnieri, and Camellia sinensis. Furthermore, it discusses preclinical and clinical studies supporting their efficacy, limitations, and future research directions in neurodegenerative therapy.
Downloads
References
Agnihotri, A., & Aruoma, O. I. (2020). Alzheimer’s disease and Parkinson’s disease: a nutritional toxicology perspective of the impact of oxidative stress, mitochondrial dysfunction, nutrigenomics and environmental chemicals. Journal of the American College of Nutrition, 39(1), 16-27.
Bássoli, R. M. F., Audi, D., Ramalho, B. J., Audi, M., Quesada, K. R., & Barbalho, S. M. (2023).
The effects of curcumin on neurodegenerative diseases: A systematic review. Journal of Herbal Medicine, 42, 100771.
Bej, E., Cesare, P., Volpe, A. R., d’Angelo, M., & Castelli, V. (2024). Oxidative stress and neurodegeneration: insights and therapeutic strategies for Parkinson’s disease. Neurology International, 16(3), 502-517.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
