Fabrication and Characterisation of tranexamic acid impregnated resorbable gauze
DOI:
https://doi.org/10.48047/xp80gr58Keywords:
Biomaterials, Electrospinning,Hemostatic agent, Tranexamic acid, Resorbable gauze.Abstract
Aim: This study aims to develop and characterize a resorbable gauze impregnated with tranexamic acid (TXA) to enhance hemostatic efficiency while ensuring controlled drug release and biodegradability. Methods: The gauze was fabricated using a combination of polyvinyl alcohol (PVA) and chitosan, with TXA incorporated through electrospinning. Morphological characterization was performed using scanning electron microscopy (SEM), while chemical interactions were analyzed via Fourier Transform Infrared Spectroscopy (FTIR).
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References
Emilia M, Luca S, Francesca B, et al. Topical hemostatic agents in surgical practice. Transfus Apher Sci. 2011;45(3):305–311. [PubMed: 22040778]
Grotenhuis R, van Grunsven PM, Heutz W, Tan E. Prehospital use of hemostatic dressings in emergency medical services in the Netherlands: a prospective study of 66 cases. Injury. 2016;47(5):1007–1011. [PubMed: 26830121]
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