“Unveiling the Anti-Diabetic Potential of Lindernia ciliata by using in-vitro methods: Phytochemical Insights and Mechanistic Pathways"

Authors

  • ANJU DAS Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India. Author
  • GEETHA K M Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India Author

DOI:

https://doi.org/10.48047/nkfmqv13

Keywords:

L. ciliata; Diabetes Mellitus; Glucose uptake assay; Insulin secretion; RIN-5F cells

Abstract

Objective: To evaluate the phytochemical screening and anti-diabetic activity of different fractions obtained from the hydroalcoholic extract of Lindernia ciliata (Colsm.) Pennell. Methodology: The hydroalcoholic extract of L. ciliata, a member of the Linderniaceae family, was fractionated using petroleum ether, chloroform, methanol, and water. These fractions were analyzed for secondary metabolites through phytochemical screening, and the total phenolic and flavonoid contents were determined. The anti-diabetic activity of the fractions was assessed using multiple assays, including glucose absorption, glucose uptake, insulin secretion by RIN-5F cells, α-amylase inhibition, and DPP-4 inhibition. 

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References

Jha, D. K., Koneri, R., & Samaddar, S. (2019). Antidiabetic activity of phytosaponin in STZ-induced Type I diabetes in rats. Research Journal of Pharmacy and Technology, 12(8), 3919–3926. https://doi.org/10.5958/0974-360X.2019.00675.9 2. Dewanjee, S., Das, A. K., Sahu, R., & Gangopadhyay, M. (2009). Antidiabetic activity of Diospyros peregrina fruit: Effect on hyperglycemia, hyperlipidemia, and augmented oxidative stress in experimental type 2 diabetes. Food and Chemical Toxicology, 47(10), 2679–2685.

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Published

2025-02-20

Issue

Vol. 54 No. 4 (2025): Year 2025, Volume 54, Issue 4

Section

Articles

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How to Cite

DAS, A., & K M, G. (2025). “Unveiling the Anti-Diabetic Potential of Lindernia ciliata by using in-vitro methods: Phytochemical Insights and Mechanistic Pathways". Cuestiones De Fisioterapia, 54(4), 6537-6552. https://doi.org/10.48047/nkfmqv13