DEVELOPMENT AND EVALUATION OF ALCOHOL RESISTANT FORMULATION BY USING DIFFERENT POLYMERS TO AVOID DOSE DUMPING
DOI:
https://doi.org/10.48047/h88gt541Keywords:
Immediate release min-tablets, Extended-release tablet, enteric coating, alcohol resistant coating.Abstract
The objective of the proposed research work is to develop a novel technology for alcohol resistant modified
release (MR) formulation, to overcome the problems of fast dissolution of MR formulation when taken with
alcohol. To maintain the desired retention time of MR formulation in body irrespective of in-take fluid with
which drug is administered and implementation of full factorial design to optimize the formulation.
Preformulation studies which include various identification tests like organoleptic properties,
solubility analysis, melting point determination, Evaluation of different grades polymers like compatibility
studies with the selected model drugs. Formulation design and optimization without impacting the
therapeutic efficacy of drug product.
Dose dumping is a phenomenon of drug metabolism in which environmental factors can cause the premature
and exaggerated release of a drug. This can greatly increase the concentration of a drug in the body and
thereby produce adverse effects or even drug-induced toxicity.
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