Recent Advances in the Pharmacological Potential of Quercetin and Kaempferol: Mechanisms, Therapeutic Applications, and Future Perspectives- A Comprehensive Review
DOI:
https://doi.org/10.48047/ezjs6d05Keywords:
Quercetin, Kaempferol, Flavonoids, Antioxidant, Anti-inflammatory, Bioavailability, Synergistic effects, Therapeutic applications, Drug delivery systems.Abstract
Quercetin and kaempferol, two ubiquitously distributed flavonoids, have emerged as front-runners in the quest
for natural compounds with multifaceted therapeutic potential. Over the past decade, research has unveiled
their profound antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuroprotective properties,
positioning them as promising for both preventive and adjunctive therapies. Their ability to modulate signaling
pathways such as NF-κB, PI3K/Akt, and Nrf2 underscores their pleiotropic effects, while advancements in
nanotechnology have addressed longstanding bioavailability challenges. For instance, quercetin-loaded
nanoparticles have shown a 300% increase in plasma concentration in preclinical models, enhancing its
efficacy in mitigating oxidative stress and inflammation Similarly, kaempferol glycosides derived from saffron
exhibit improved gastrointestinal stability, broadening their clinical applicability. I
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
