Assessment of Hepatoprotective Potential of Dendrobium bicameratum, a Bryophyte from Eastern Ghats, Odisha
DOI:
https://doi.org/10.48047/9emmpf45Keywords:
Dendrobium bicameratum, hepatoprotective, SGOT, SGPT, total albumin, total protein.Abstract
An investigation was conducted to assess the hepatoprotective potential of hydroalcoholic and
aqueous extracts of Dendrobium bicameratum in Wistar rats with carbon tetrachloride (CCl4)-induced hepatic
damage. The extent of liver injury was evaluated by measuring serum biomarkers, including SGOT, SGPT,
total albumin, total protein, IL-1β, IL-6, and TNF-α. Administration of hydroalcoholic (HADBM) and aqueous
(ADBM) extracts at 200 mg/kg, as well as silymarin (100 mg/kg), demonstrated significant (P < 0.05)
hepatoprotective effects by reducing the levels of serum hepatoprotective and inflammatory mediators. These
findings suggest that Dendrobium bicameratum extracts exhibit pronounced hepatic protection, comparable
to the standard hepatoprotective agent silymarin.
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