Effect of Centella asiatica leaf extract on the transgenic Drosophila model of Parkinson’s disease
DOI:
https://doi.org/10.48047/n9qr8r68Keywords:
Centella asiatica, Neurodegenerative disorder, Oxidative stress, Parkinson’s diseaseAbstract
Parkinson's disease (PD) is a progressive neurodegenerative disease that causes motor and cognitive deficits due to α-synuclein aggregation and dopaminergic neuron loss. One of the most important factors in PD pathogenesis is oxidative stress. Parkinson disease transgenic Drosohphila model is used to examine the neuroprotective potential of Centella asiatica, a medicinal plant with antioxidant qualities. TH-GAL4 females were crossed with UAS-SNCA males to create transgenic PD model flies that express
human α-synuclein in dopaminergic neurons.
Downloads
References
Dinda, B., Dinda, M., Kulsi, G., Chakraborty, A., & Dinda, S. (2019). Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European Journal of Medicinal Chemistry, 169, 185-199.
Abdul-Muneer, P. M., Chandra, N., & Haorah, J. (2015). Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Molecular neurobiology, 51, 966-979.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
