Histopathological Changes in Liver of Albino Rat Exposed by Endosulfan
DOI:
https://doi.org/10.48047/h1698r51Keywords:
Endosulfan, Histological changes, Liver, Toxicity.Abstract
Despite its extremely harmful effects, endosulfan, an organochlorine insecticide, is a commonly used pesticide in agriculture. Consequently, the study's goal was to ascertain how endosulfan affected the albino rats' liver' histology. Endosulfan was administered orally to male rats at low, medium, and high doses (3.5, 7, and 10.5 mg/kg) for a duration of 15, 30, and 45 days.
Increased of ALP and AST, mild diltation and congestion progressed to severe necrosis, cellular swelling, infiltration of kupffer cells, degeneration and disarrangement of hepatic cords at higher doses and prolonged exposure. In conclusion, endosulfan damaged and was harmful to liver. This pesticide caused oxidative stress in liver; Oxidative stress was shown to be increase in oxygen free radical production. Thus, that lead to be alteration in histology and function of liver male albino rat.
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