Synthesis, Characterization, and Pharmacological Evaluation of Metal-Chelating Compounds for Neuroprotection in Oxidative Stress-Induced Neuronal Damage
DOI:
https://doi.org/10.48047/xpf7f052Keywords:
L2-Cu and L1-Cu complexes exhibited the highest neuroprotection, restoring cell viability to 88.9% and 85.6%, respectively, compared to 48.2% in H₂O₂-treated cells.Abstract
Background:
Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are associated with oxidative stress and metal ion dysregulation, leading to neuronal damage. Excessive accumulation of metal ions such as Fe³⁺, Cu²⁺, and Zn²⁺ catalyzes reactive oxygen species (ROS) generation, exacerbating neuronal apoptosis. Metal-chelating compounds have emerged as potential
neuroprotective agents by regulating metal homeostasis and reducing oxidative stress.
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References
Barnham, K. J., Bush, A. I., & Tanzi, R. E. (2023). Metals and oxidative stress in neurodegenerative diseases. Nature Reviews Neuroscience, 24(1), 45-61. https://doi.org/10.1038/s41583-023-01123-4
Chen, L., Zhang, X., Wang, Y., & Li, Y. (2023). Reactive oxygen species and neurodegeneration: Mechanisms and therapeutic implications. Journal of Neurochemistry, 167(3), 567-583. https://doi.org/10.1111/jnc.15789
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