AI-Powered CRISPR-Cas9: Precision Therapeutics for ATP7B Mutations in Wilson Disease and Restoring Copper Metabolism
DOI:
https://doi.org/10.48047/ms6yjk43Keywords:
.Abstract
Introduction: Wilson Disease is a genetic disorder caused by a mutation in ATP7B gene that leads to toxic copper accumulation in vital organs such as the liver, brain, kidneys, and eyes. The copper overload results in severe liver dysfunction, neurological problems, kidney impairment, and the hallmark feature called KayserFleischer rings in the eyes, which becomes progressively life-threatening if left untreated. With recent technological advancements, this research aims to explore the potential of using Artificial Intelligence (AI) with CRISPR-Cas9 gene-editing technology to develop precision therapies for correcting ATP7B mutations (28,29).
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References
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNAguided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337(6096):816-21. 2. Doudna JA, Charpentier E. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014;346(6213):1258096.
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