A CHALLENGES AND CLINICAL IMPLICATION IN DAPSONEINDUCED HYPERSENSITIVITY SYNDROME IN BORDERLINE TUBERCULOID HANSEN'S DISEASE
DOI:
https://doi.org/10.48047/5490j172Keywords:
Dermatological Disorders, Borderline Tuberculoid Leprosy, Dapsone Hypersensitivity Syndrome (DHS), Hyperpigmented Patches.Abstract
An essential sulfone medication, dapsone was created in 1908 and is mostly used to treat leprosy and other
dermatological disorders. 0.2% to 0.5% of users have dapsone hypersensitivity syndrome (DHS), which was
initially identified in 1949. If left untreated, DHS can cause severe systemic symptoms that could result in organ
damage or even death. DHS is characterised by a delayed onset that can happen anywhere from two hours to
six months after exposure. It involves processes such as the creation of inflammatory cytokines. Skin
hypersensitivity responses and haemolytic anaemia associated to dosage are important adverse effects.
A 42-year-old housewife with borderline tuberculoid leprosy showed up with extensive red lesions that turned
into yellowish pustules over the course of four days, as well as hand and foot oedema, pain, and itching. A
trophic ulcer on her right sole, hyperpigmented patches, and non-blanchable erythema and pustules on her
face, upper and lower limbs, chest, and belly were all found during the examination. She had steady vital signs
and no systemic symptoms.
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