To assess the anticancer potential and design a nano delivery system for newly synthesized thioamide derivatives.
DOI:
https://doi.org/10.48047/50ymdy80Keywords:
Thioamide derivatives, anticancer activity, nano delivery system, cytotoxicity, targeted drug delivery, nanoparticles.Abstract
This study aims to evaluate the anticancer efficacy of newly synthesized thioamide derivatives and to develop a nano delivery system to enhance their therapeutic potential. Thioamide derivatives have shown promise in cancer treatment due to their cytotoxic effects
on malignant cells, yet challenges remain in achieving efficient delivery, stability, and targeted action. To address these limitations, a nano delivery system was developed, focusing on optimizing particle size, surface charge, and release characteristics to improve
cellular uptake and bioavailability. The synthesized thioamide derivatives were first screened for characterization studies, including fourier-transform infrared spectroscopy (FTIR), confirmed the stability and encapsulation efficiency of the nanoparticles. The
results suggest that the nanodrug delivery system not only improves the anticancer efficacy of thioamide derivatives but also offers a promising approach for targeted cancer therapy. This study paves the way for further in vivo studies and the potential clinical application of nanoformulated thioamides in cancer treatment, providing a significant advancement in the development of novel chemotherapeutic strategies.
Downloads
References
Ahmad, N., Alam, M. A., Ahmad, R., & Naqvi, A. A. (2019). Novel drug delivery applications of thioamides: Synthesis, characterization, and in vitro anticancer activity. European Journal of Pharmaceutical Sciences, 136, 104947.
Jain, R. K., Stylianopoulos, T. (2010). Delivering nanomedicine to solid tumors. Nature Reviews Clinical Oncology, 7(11), 653-664.
Mukherjee, B., Paul, P., & Patra, B. (2017). Characterization of biodegradable polymeric nanoparticles for sustained delivery of anticancer drugs. Journal of Controlled Release, 266, 131-144.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
