Exploring The Nipah Virus: Insights Into Pathogenesis And Therapeutic Approaches
DOI:
https://doi.org/10.48047/acfxav57Keywords:
Nipah virus, BSL-4 pathogen, Antiviral drugs, Vaccines, computational approaches, molecular targetsAbstract
Nipah virus (NiV), classified as a biosafety level-4 (BSL-4) pathogen, poses a significant challenge in the field of infectious diseases, as its capacity to move between animals and humans raises serious global health concerns. This analysis explores the historical progression of NiV outbreaks, examining its effects on communities globally. This study investigates the emergence and epidemiology of the virus, focussing on its transmission dynamics and the significant impact it has had on affected regions. The neurological sequelae observed in survivors highlight the critical need for thorough care strategies. The exploration of molecular
targets for antiviral drug development and current vaccine initiatives is undertaken, in conjunction with computational strategies in drug design. Targeting Ephrin-B2 and Ephrin-B3 presents a promising approach in NiV therapeutics, providing specificity and the potential for broad-spectrum activity.
Downloads
References
Harcourt, B. H. et al. Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 271, 334–349 (2000).
Yob, J. M. et al. Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia. Emerg. Infect. Dis. 7, 439–441 (2001).
Harcourt, B. H. et al. Molecular characterization of the polymerase gene and genomic termini of Nipah virus. Virology 287, 192–201 (2001).
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
